ToolsΒΆ
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Compute change in fate probabilities towards terminal states after perturbation. |
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Add inference results to adata. |
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Perform an in silico transcription factor (TF) regulon knock-out by modifying the gene regulatory network (GRN) in a trained RegVelo model. |
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Perform in silico TF regulon knock-out screening |
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Perform repeated in silico TF regulon knock-out screening. |
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Simulate transitions on a velocity-derived Markov transition matrix. |
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Compute difference scores and p-values for terminal states between baseline and perturbation simulations. |